The Effect and Safety Profile of Thymoglobulin® in Primary Cardiac Transplant Recipients

Exclusion Criteria

• •1. Allergy to Thymoglobulin-Thymoglobulin is contraindicated in patients with history of allergy or anaphylaxis to rabbit proteins or to any product excipients, or who have active acute or chronic infections which contraindicate any additional immunosuppression
• •2. Previous organ transplants
• •3. Patients receiving multiple organs
• •4. Patients with a BMI higher than 35
• •5. Patients with PRA ≥ 25%
• •6. Patients requiring VAD upon completion of transplantation surgery.
• •7. HIV-1, HTLV-1, chronic Hepatitis B, or chronic Hepatitis C infection
• •8. Documented or strong suspicion for pre-operative active infection that has not yet been adequately treated with the recommended course of antimicrobial therapy
• •9. Presence of any chronic myelosuppressive disease or agent that has resulted in either chronic leucopenia or chronic thrombocytopenia
• •10. Active peptic ulcer disease and active GI bleeding
• •11. Patients who have received within the past 30 days or require concomitant treatment with other investigational drugs (except for those listed in section 8.6 "Concomitant treatment")
• •12. Patients with a history of AL amyloidosis (TTR amyloids) are permitted