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UNKNOWNPHASE4

Effect of Alfacalcidol to Respiratory Infection and Immune Response of Indonesian Elderly

Effect of Alfacalcidol Supplementation to Respiratory Infection, Inflammatory Markers and CD4/CD8 Ratio of Indonesian Elderly

NCT03292744•Indonesia University

View on ClinicalTrials.gov

Summary

Vitamin D has been known to influence immune response through Vitamin D Receptor in Immune Cells, but only few has been known about the effect alfacalcidol, a vitamin D analog to immune system. In elderly, immune disregulation or immunosenecence have great impact to infection response. This study is aimed to determine the effect of alfacalcidol supplementation in vitro and in vivo to respiratory infection incidence and inflammatory markers, as well as T cell lymphocyte subset in Indonesian elderly patients.

Detailed Description

This study consist of 2 designs. First is in vitro study to investigate the effect of alfacalcidol supplementation to IL-6, IL-10 and IFN gamma regulation in Peripheral Blood Mononuclear Cells (PBMC) of elderly and second design is randomised controlled trial to evaluate the effect of 3 months supplementation of alfacalcidol 0,5 mcg in respiratory infection, antibiotic use, inflammatory markers, CD4/CD8 ratio and CD8+ CD28+ in Indonesian elderly with various level of frailty syndrome.

Eligibility

Age

60 - No limit years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Elderly age more than 60
•Willing to join research

Exclusion Criteria

•In acute infection
•Using NSAID or steroid
•Liver failure
•Hypercalcemia

Locations (1)

Cipto Mangunkusumo National Hospital

Jakarta, Indonesia

Key Dates

Start Date

January 10, 2017

Primary Completion Date

October 10, 2017

Completion Date

December 15, 2017

Last Updated

September 26, 2017

Enrollment

110

ESTIMATED participants

Conditions

Frail Elderly SyndromeElderly Infection

Interventions

Alfacalcidol

DRUG

Contacts

Aulia Rizka, MD

CONTACT

+628125265600 dr.auliarizka@yahoo.co.id

Aulia Rizka, MD

CONTACT

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Elderly InfectionFrailty+2 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 26, 2017Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Effect of Alfacalcidol to Respiratory Infection and Immune Response of Indonesian Elderly

Inclusion Criteria

Exclusion Criteria

Antibiotic Dosing in Geriatric Patients At the Emergency Department

Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Women

Implementing, Evaluating, and Scaling Up of the Strengthening a Palliative Approach in Long Term Care (SPA-LTC) Program

Frailty Assessment by Edmonton Frail Scale to Predict Outcome in Patients Undergoing Cardiovascular Surgery

Long COVID and Its Associations With Health Outcomes in Older Adults

Comparative Analysis of Risk Factors and Prediction of Frailty Syndrome