Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Maastricht University Medical Center
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
In order to be eligible to participate in this study, a subject must meet all of the following criteria:
All patients:
* Age18years and older (no maximum age)
* Informed consent by signed informed consent form regarding this study
Patients, who are scheduled for carotid endarterectomy:
* Symptomatic stenosis (TIA or CVA) within last 14days and high grade stenosis (70-99%)
* In men, carotid artery stenosis between 50-69% is considered significant when related to clinical symptoms
Patients, who are not scheduled for carotid endarterectomy:
* Patients who have experienced a TIA/CVA/amaurosis fugax (a 'TIA of the eye') within the last 14 days and abnormal findings on imaging of the carotids:
* Women with an ipsilateral carotid artery stenosis between 30-69% based on duplex ultrasonography, CTA, or MRA
* Men with an ipsilateral carotid artery stenosis between 30-49% based on duplex ultrasonography, CTA, or MRA
You may not be if
All patients:
* Severe cognitive impairment, neurological deficit or comorbidity causing the study to be too high a burden for the patient or disrupting patient's co- operation with scan procedures
* Evident other causality for stroke (cardiac embolus, small vessel disease or thrombogenic diathesis)
* Pregnant women and nursing mothers
* Contra-indications for MRI (49):
* Ferromagnetic implants, such as pacemakers and other electronic implants
* Ferromagnetic (intracerebral) vascular clips
* Metallic cochlear implants
* Metallic splinters in eye(s) or other magnetic metallic foreign bodies elsewhere
* Claustrophobia
* Relative contra-indications for MRI-contrast agents (50):
* GFR \<30ml/min/1,73m2
* Previous allergic reaction to MRI contrast agent
* Contra-indication 18F-Flutemetamol:
* Known allergic reaction to flutemetamol or polysorbate 80 or any of the excipients.
* Severe liver dysfunction.
Patients undergoing CEA:
* Comorbidity associated with high operative risk
* Occlusion of the internal carotid artery on the symptomatic side
* Near occlusion on the symptomatic side
* Complete infarction of the symptomatic anterior circulation/severe neurological deficit
