Age

40–80

Sex

ALL

Healthy volunteers

Not accepted

Patients with written inform consent to participate in the study and all the following criteria will be selected:
Age 40-80 years
Smokers or exsmokers of at least 10 pack-years
Moderate-to-severe COPD

Non-stable COPD. Stability is defined as being exacerbation free and without treatment changes for at least 4 weeks prior to baseline evaluation. The presence of a COPD exacerbation previous to the sleep studies (polysomnography, actigraphy, OSLER test) will lead to an early discontinuation of the patient´s participation in the study.
Heart failure, asthma, cancer or other major medical illness with known effects on sleep quality.
Unable to understanding the questionnaires administered in the study.
Known Obstructive Sleep Apnea, other sleep disorder (narcolepsy, periodic limb movements) or shift work.
Chronic respiratory failure (PaO2 \<60 mmHg).
Treatment with sedatives or antidepressants.

Sleep Quality in (COPD) Patients (COPD: Chronic Obstructive Pulmonary Disease)