A Prospective Study of Application of Platelet Mapping in HBV-related Acute-on-chronic-liver Failure in China

Exclusion Criteria

• •INR≤1.5 or total bilirubin≤85μmol/L;
• •underlying chronic liver disease was other than chronic HBV infection related;
• •those who had hepatocellular carcinoma or other types of malignancies;
• •obstructive biliary diseases or other disease lead to bilirubin evaluation;
• •those who had acute hemorrhage one week before admission
• •those who received platelet, cryo transfusion or plasmapheresis one week before admission
• •using steroid or immunosuppressant or antiplatelet or anticoagulant drugs in 4 weeks
• •any kind of decompensation which persisted over a month
• •pregnancy and breastfeeding
• •those who received liver transplantation or kidney transplantation;
• •combine with other disease lead to organ failure including heart failure (NYHA IV),respiratory failure（PaO2\<60mmHg),renal insufficiency(CKD 5) and conscious disturbance (GCS\<8)
• •readmission;
• •death within 24 hours.