Efficacy of Periodontal Treatment on Systemic Inflammation and for Prevention of Exacerbations in Patients With COPD

Inclusion Criteria

• •COPD functional class B to D (moderate to very severe) according to the Global Initiative For Chronic Obstructive Lung Disease (GOLD)
• •age ≥ 40 and ≤ 80 years
• •at least 10 natural teeth
• •COPD-associated hsCRP elevation (after exclusion of infection) with hsCRP \> 3mg/l
• •presence of chronic periodontitis
• •at least 1 exacerbation leading to treatment with systemic glucocorticoids or antibiotics or hospitalization within the last 12 months
• •non-smoker or ex-smoker for at least the last 6 months
• •ability to understand the character and individual consequences of participation in this trial and to give written informed consent
• •provision of a written informed consent to participation in the trial prior to trial start and any trial-related procedures