A Pilot Study of FOLFIRINOX in Combination With Neoadjuvant Radiation for Gastric and GE Junction Cancers

This research study is a Pilot Study, which is the first time investigators are examining this study intervention. In this research study, the investigators are studying the combination of FOLFIRINOX followed by radiation with paclitaxel and carboplatin before surgery. The investigators believe that this intervention may help decrease the growth and spread of the cancer cells. FOLFIRINOX has shown to be very effective in patients whom disease has spread. The investigators are evaluating this regimen to see if there is an increase in curability when the cancer has not spread. The FDA (the U.S. Food and Drug Administration) has approved FOLFIRINOX as a treatment option for this disease. The FDA has not approved Paclitaxel or Carboplatin for this specific disease but they have both been approved for other uses. FOLFIRINOX is a combination of 4 chemotherapy agents that may help shrink the tumor before surgery. Carboplatin may stop the cancer cells from growing and paclitaxel may stop the cancer cells from growing and spreading