Adolescent Master Protocol for Participants 18 Years of Age or Older - Lite

This is a prospective cohort study designed to define the impact of HIV infection and antiretroviral therapy (ART) on young adults with perinatal HIV infection as they transition to adulthood. The primary objectives of this study are: 1. To identify infectious and non-infectious complications of HIV disease and toxicities resulting from long-term ART, including disease progression, immune suppression, viral resistance, end-organ disease, and mortality. 2. To define the impact of HIV infection and ART on the long-term clinical outcomes of young adults with perinatal HIV. 3. To define the impact of perinatal HIV infection and ART on long-term mental and behavioral health outcomes.