To Assess the Safety of Continuous IV Administration of Plerixafor and Assess Impact on the Immune Microenvironment in Patients With Pancreatic, Ovarian and Colorectal Adenocarcinomas

Exclusion Criteria

• •Inadequate haematological function defined by:
• •* Absolute neutrophil count (ANC) \<1.5 x 109/L
• •* Absolute lymphocyte count \<1.0 x 109/L (counts shall be rounded to the nearest tenth. (e.g. 0.96 will be rounded to 1.0 x 109/L))
• •* Haemoglobin \<9.0 g/dL (90 g/L) (may be increased to this level with transfusion as long as there is no evidence of active bleeding)
• •* Platelets \<100 x 109/L
• •* Clotting; INR \>1.3
• •Inadequate renal function defined by calculated creatinine clearance by Cockcroft-Gault of \<50 ml/min.
• •Inadequate hepatic function defined by:
• •* Aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) \>2.5 x upper limit of normal (ULN) or \>5 x in the presence of liver metastases
• •* Total bilirubin \>1.5 x ULN
• •Current treatment (within 28 days of entry) with chemotherapy, steroids or other immunosuppressive drugs.
• •Significant acute or chronic medical or psychiatric condition, disease or laboratory abnormality which in the judgment of the Investigator would place the patient at undue risk or interfere with the trial.
• •Cardiac co-morbidity:
• •* Past history of significant rhythm disturbance (e.g. SVT, AF or ventricular irregularities)
• •* Requirement for pacemaker
• •* Myocardial infarction in the previous 6 months
• •* Known medical history of proven postural hypotension.
• •Active infection.
• •Patients with known allergy to plerixafor or its excipients.
• •Patients known to have hepatitis B, hepatitis C or HIV infection.
• •Participation in any other interventional clinical trial
• •Women, who are pregnant, plan to become pregnant or are lactating (during the trial or for up to 3 months after the last dose)