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Primary Graft Dysfunction Score in Lung Transplantation

Finding New Criteria for a Revised Primary Graft Dysfunction Score in Lung Transplantation - a Pilot Study

NCT03276403•Assoc.-Prof. Dr. Konrad Hoetzenecker, PhD

Summary

The validity of several functional parameters, which could be included in a new PGD scoring system, will be tested in a prospective pilot study of 80 consecutive bilateral lung transplant recipients in high volume lung transplant centers. Functional parameters will be collected at different time points within the first 72hrs after lung transplantation and their accuracy in predicting clinical outcome as well as their correlation with lung water content (measured by PiCCO) will be tested. Insights will serve to generate a hypothesis (a novel PGD score), which can then be tested in future prospective trials.

Eligibility

Age

18 - 80 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Double lung transplantation for primary pulmonary hypertension (PPH), Fibrosis, cystic fibrosis (CF), Emphysema
•No restrictions regarding donor lungs (marginal donors, EVLP possible)
•No restrictions regarding size reduction (anatomic wedge resections, three lobar, lobar transplantations)

Exclusion Criteria

•Single-lung transplantation
•Heart-lung transplantation
•Re-transplantation
•Patients with bridge-to-transplantation with a mechanical assist device (extra-corporal membrane oxygenation (v/v, v/a), PA/LA Novalung, ILAactive, ILA)
•Clinical situations leading to inaccurate PiCCO measurements e.g. intracardiac shunts, significant tricuspid regurgitation, cooling
•No access to the femoral artery possible
•Severe postoperative hemorrhage, which leads to hematothorax and makes revision surgery necessary

Locations (2)

Medical University of Vienna

Vienna, Austria

Toronto General Hospital

Toronto, Ontario, Canada

Key Dates

Start Date

November 1, 2016

Primary Completion Date

December 1, 2017

Completion Date

March 1, 2018

Last Updated

September 8, 2017

Enrollment

ESTIMATED participants

Conditions

Lung Transplant; Complications

Interventions

PiCCO Catheter

DEVICE

Contacts

Konrad Hoetzenecker, MD, PhD

CONTACT

0043140400 konrad.hoetzenecker@meduniwien.ac.at

Thomas Schweiger, MD, PhD

CONTACT

0043140400 thomas.schweiger@meduniwien.ac.at

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 8, 2017Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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Primary Graft Dysfunction Score in Lung Transplantation

Inclusion Criteria

Exclusion Criteria

An Evaluation of Remote Care (questionnaire+hybrid) in Patients Who Are Post-lung Transplant

RENAL: TNF-alpha Inhibitor for Improving Renal Dysfunction and Primary Graft Dysfunction After Lung Transplant

Identifying Optimal PEEP After Lung Transplantation

Assessment of Lung Transplant Recipients Within The Scope of International Classification of Functioning, Disability and Health

Prophylactic Topical Epinephrine to Reduce Bleeding in Transbronchial Lung Biopsies

COVID19 Vaccine in SOT Adult Recipients