Single Ascending Dose Study of MEDI1341 in Healthy Volunteers

Exclusion Criteria

• •Nicotine use within 6 months before screening
• •Considered to be at a high risk of developing a stroke
• •Significant medical history of dizziness, blackouts, fainting, or vaso-vagal attacks
• •History of any significant ophthalmic disorder, including congenital, genetic or acquired conditions affecting the retina or choroid
• •History of severe allergy or history of hypersensitivity to immunizations or immunoglobulins
• •History of any significant psychiatric disorder
• •History of alcohol abuse
• •History of cancer within 5 years of screening
• •History of drug abuse
• •Any contraindication to Lumbar Puncture
• •Any clinically significant abnormality in ECG rhythm, conduction or morphology
• •Positive serologic findings at screening for human immunodeficiency virus (HIV) antibodies, hepatitis B surface antigen, or hepatitis C virus antibodies
• •Use of prescription or non-prescription drugs
• •For female participants, a positive serum or urine pregnancy test result at screening