Short Term Effect of Glucocorticoids on Brown Adipose Tissue Thermogenesis in Humans

Exclusion Criteria

• •Cold induced thermogenesis of less than 5% basal metabolic rate (determined during screening visit)
• •Contraindications to the class of drugs under study, e.g. known hypersensitivity or allergy to class of drugs or the investigational product,
• •History of depressive disorder, anxiety disorder
• •History of tuberculosis or latent infection
• •Increased intraocular pressure
• •History of peptic / gastrointestinal ulcer disease
• •Concomitant medication: Non-steroidal anti-inflammatory drugs (NSAID), other glucocorticoids, diuretics, antihypertensives, fibrates or statins, metformin
• •Other clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, diabetes mellitus),
• •Hypersensitivity to cold (e.g. Raynaud Syndrome)
• •Allergy to local anesthetic
• •Known or suspected non-compliance, drug or alcohol abuse,
• •Inability to follow the procedures of the study
• •Participation in another study with investigational drug within the 30 days preceding and during the present study,
• •Previous enrolment into the current study,
• •Enrolment of the investigator, his/her family members, employees and other dependent persons,
• •Hypothyroidism without sufficient substitution
• •Claustrophobia
• •MRI incompatible implants
• •Enrolment into another study using ionizing radiation within the previous 12 months.