Loading clinical trials...
Loading clinical trials...
Effects of Dapagliflozin on Lipoprotein Kinetics in Patients With Type 2 Diabetes
This study will make it possible to better understand the mechanisms responsible for the increase in bad cholesterol levels observed in patients with type 2 diabetes treated with Dapagliflozin, an antidiabetic treatment made by Astrazeneca. The information will: * reveal what is not working properly * make it possible to choose the most appropriate treatments against cholesterol to compensate for this impaired functioning This biomedical research will take place at the University Hospitals of DIJON and NANTES. * 28 patients will take part: 20 patients will be given Dapagliflozin and 8 patients will be given the placebo. * The study treatment will be randomised: patients will be given either Dapagliflozin or the placebo. The treatment duration is 6 months. * Moreover, during the inclusion visit and at the end of the study (6 months after the start of treatment), a kinetics study, to follow the production and elimination of cholesterol, will be conducted. This will involve administering amino acids that have been specifically synthesised for this purpose. * Participation in the study will last 6 months and include 4 protocol visits.
Age
30 - 65 years
Sex
ALL
Healthy Volunteers
No
CHU Dijon Bourgogne
Dijon, France
Start Date
December 20, 2017
Primary Completion Date
May 6, 2021
Completion Date
May 6, 2021
Last Updated
March 5, 2026
28
ACTUAL participants
Dapagliflozin
DRUG
Placebos
DRUG
Lead Sponsor
Centre Hospitalier Universitaire Dijon
NCT02191644
NCT01422057
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.
View ClinicalTrials.gov Terms and Conditions