Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Massachusetts General Hospital
Age
21–80
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Healthy Volunteers
Subjects must be ≥21 and ≤80 years of age;
Subjects must provide informed consent prior to study procedures;
Subjects must be ≥21 and ≤80 years of age;
Subjects must provide informed consent prior to study procedures;
History of scar-mediated ventricular arrhythmia scheduled for invasive EAM-guided catheter ablation for clinical care
You may not be if
Known structural heart disease (e.g. myocardial infarction);
History of ventricular arrhythmia;
Any contraindication to MRI and/or PET, including:
Subjects with life vest;
Subjects with implanted heart device (e.g. ICD, Pacemaker);
Subjects with metallic fragment or foreign body;
Subjects with other form of devices or prosthesis that are not MRI compatible, such as insulin pump, joint replacement, hearing aid, cochlear implant, permanent contraceptive devices, etc.;
Claustrophobia;
Relative or absolute contraindication to Dotarem contrast:
history of renal disease including acute or chronic severe renal insufficiency (glomerular filtration rate \<60 mL/min/1.73m2);
a history of diabetes mellitus, systemic lupus, multiple myeloma, nephrogenic systemic fibrosis, and other co-morbidities;
History of hypersensitive reactions to Dotarem and/or gadolinium contrast agent
Any clinically significant acute or unstable physical or psychological disease, judged by the investigators based on medical history or screening physical examination, to be incompatible with the study;
Any physical or psychological disease judged by the investigators to be incompatible with the study, based on medical history or screening physical examination
Radiation exposure exceeds current Radiology Department guidelines (i.e. 50 mSv in the prior 12 months);
Female subjects only: Positive serum and/or urine pregnancy test, or lactating, or possibility of pregnancy cannot be ruled out prior to dosing;
Inability to provide written informed consent;
Arrhythmia Subjects:
Any contraindication to MRI and/or PET, including:
Subjects with life vest;
Subjects with implanted heart device (e.g. ICD, Pacemaker);
Subjects with metallic fragment or foreign body;
Subjects with other form of devices or prosthesis that are not MRI compatible, such as insulin pump, joint replacement, hearing aid, cochlear implant, permanent contraceptive devices, etc.;
Claustrophobia;
Relative or absolute contraindication to Dotarem contrast:
history of renal disease including acute or chronic severe renal insufficiency (glomerular filtration rate \<60 mL/min/1.73m2);
history of diabetes mellitus, systemic lupus, multiple myeloma, nephrogenic systemic fibrosis, and other co-morbidities;
History of hypersensitive reactions to Dotarem and/or gadolinium contrast agent;Any clinically significant acute or unstable physical or psychological disease, judged by the investigators based on medical history or screening physical examination, to be incompatible with the study;
Any physical or psychological disease judged by the investigators to be incompatible with the study, based on medical history or screening physical examination
Radiation exposure exceeds current Radiology Department guidelines (i.e. 50 mSv in the prior 12 months);
Female subjects only: Positive serum and/or urine pregnancy test, or lactating, or possibility of pregnancy cannot be ruled out prior to dosing;
