Adjuvant Therapy With Apatinib for HCC Patients With PVTT Who Underwent Radical Resection

Exclusion Criteria

• •1. Hepatic duct carcinoma、mixed cell carcinoma and fiberboard layer cell carcinoma which have confirmed; Past (5 years) or current with other malignant tumor, except skin basal cell carcinoma and cervical carcinoma in situ.
• •2. Patients with hypertension who are unable to fall within normal range by antihypertensive medications (systolic pressure \> 140 mmHg, diastolic pressure \> 90 mmHg).
• •3. With the second level of myocardial ischemia or myocardial infarction, poor control of the arrhythmia (including QTc interval = 450 ms, male female = 470 ms).
• •4. Factors that affect oral medication, such as inability to swallow, chronic diarrhea and intestinal obstruction, which significantly affect the use and absorption of drugs.
• •5. Ascites with clinical symptoms requires therapeutic peritoneal paracentesis or drainage.
• •6. In the past 6 months, with the history of alimentary tract hemorrhage or definite gastrointestinal bleeding tendency, such as: the risk of bleeding esophageal varices, local active ulcerative lesions, fecal occult blood; For those with fecal occult blood (+), gastroscopy is required.
• •7. Abdominal fistula, gastrointestinal perforation, or abdominal abscess occurred within 28 days before entry;
• •8. Postoperative complications were not relieved.
• •9. Abnormal coagulation function (INR \> 1.5 or prothrombin time (PT) \> ULN+4 seconds), with bleeding tendency or undergoing thrombolysis or anticoagulant therapy;
• •10. Past and present pulmonary fibrosis history, interstitial pneumonia, pneumoconiosis, radiation pneumonitis, drug associated pneumonia, and severe lung function impairment;
• •11. Urine routine showed that urinary protein is more than + + or confirmed 24 hours urine protein is more than 1.0 g;
• •12. Symptomatic metastasis of the central nervous system;
• •13. Pregnant or lactating women; fertile patients who are unwilling or unable to adopt effective contraceptives;
• •14. Patient with mental illness or a history of psychotropic substance abuse;
• •15. HIV infection;
• •16. Before operation, AFP or PIVKA-2 increased, but not decreased to normal range;
• •17. HBV-DNA\>10\^3 copys/ml；
• •18. Other conditions that the investigators considered that not unsuitable for inclusion.