IMRT and Timing in Combination With EGFRTKI for Stage IV Non-small-cell Lung Cancer

Exclusion Criteria

• •Evidence of small cell, large cell neuroendocrine or carcinoid histology.
• •Non-stage IV NSCLC and ECOG performance status 3～5 or KPS\<60
• •Have a serious or uncontrolled medical condition that could compromise the patients' ability to adhere to the protocol.
• •Malignant pleural effusion and pericardial effusion
• •Uncontrolled intercurrent illness including, but not limited to, hypertension , diabetes mellitus ,ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
• •Pregnant and/or breastfeeding: Patient must have a negative pregnancy test within 14 days of study entry.
• •Have a secondary malignancy (except adequately treated non-melanomatous skin cancer, or other cancer such as in situ of the cervix. considered cured by surgical resection or radiation). Patients who have had another malignancy in the past but have been disease free for more than 5 years are eligible.
• •A history of allergic reactions attributed to compounds of similar chemical or biologic composition to EGFR-TKI or other agents used in the study.
• •With poor compliance
• •The researchers consider it inappropriate to participate in the study