Personalized Adoptive Cellular Therapy Targeting MDS Stem Cell Neoantigens (PACTN)

Exclusion Criteria

• •Subjects who anticipate use of other investigational or non-investigational agents for the treatment of MDS during the study period, aside from a stable dose of erythropoietin stimulating agent started \>8 weeks prior to screening for this study.
• •Subjects who have received investigational agents, cytotoxic chemotherapy, or radiotherapy within 28 days prior to entering the study, or who have not recovered from AEs dur to agents administered more than 28 days earlier.
• •Subjects who are less than 21 days from surgery or have insufficient recovery from surgical-related trauma or wound healing.
• •Prior history of allogeneic hematopoietic stem cell transplantation.
• •Current use of granulocyte colony-stimulating factory (G-CSF) or GM-CSF.
• •History of major organ autoimmune disease.
• •Concurrent immunosuppressive therapy. A stable dose of prednisone \<10 mg daily or inhaled corticosteroids are allowed.
• •Any form of primary immunodeficiency.
• •Active bacillus tuberculosis (TB) or any other active or uncontrolled infection.
• •Pior history of treated malignancy in the past 2 years. Subjects with non-melanoma skin cancer, localized prostate cancer, and carcinoma in situ of the breast of cervix are allowed.
• •Impaired cardiac function.
• •Pregnant women are excluded from this study as the proposed treatment has not been well studied in pregnant subjects.
• •Any other medical or psychiatric disorders, or social situation, that would, in the investigator's opinion, place the subject at unacceptable risk if he/she participates in the study.