Age

18–65

Sex

ALL

Healthy volunteers

Not accepted

DSM-5 diagnosis of a single or recurrent major depression
Failure of at least two adequate antidepressant treatments
HAMD-17 total score of ≥ 23 and a Clinical Global Impression Scale (CGI-S) of ≥ 4
Stable psychopharmacological treatment within 2 weeks prior inclusion
Age 18-65 years
Right-handedness (assessed with the Edinburgh Handedness Inventory)

Seizures in medical history
Medical history of major systemic illness, neurological disorders and previous brain injuries
Current psychotic symptoms
Substance abuse or dependence within last 3 months
Borderline personality disorder (based on DSM-5 criteria)
Pregnancy
Active suicidal intent
Benzodiazepines other than Lorazepam \< 2mg/d
failure to comply with the study protocol or to follow the instructions of the investigating team

TBS in Major Depression