Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Bayer
With
Merck Sharp & Dohme LLC
Age
30–80
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Patients with stable CAD defined by
coronary artery stenosis in any of the 3 main coronary vessels \> 50% documented by coronary angiography within last 36 months
or history of myocardial infarction
Age: 30 to 80 years (inclusive) at the first screening examination
Body mass index (BMI): above/equal 18.0 and below/equal 36.0 kg / m²
You may not be if
Intervention e.g. revascularization by percutaneous coronary intervention (PCI) and/or coronary artery bypass graft (CABG) during the last 3 months
Progressive angina with symptoms of worsening of angina within the \< 3 months prior to the first screening examination
History of recent (\< 6 months prior to the first screening examination) myocardial infarction or unstable angina
Symptomatic carotid stenosis, or transient ischemic attack or stroke within 3 months prior to the first screening examination or patients with stroke at more than 3 months prior to the first screening examination with significant residual neurologic involvement
Insulin dependent diabetes mellitus
Clinically relevant cardiac ischemia at screening
Clinical significant persistent ischemia, which should be ruled out by clinical judgment of the investigator, based on medical history, available clinical data e.g. past angiograms or preexisting or current exercise testing with any imaging technique (e.g. dobutamine stress echocardiography, adenosine or dobutamine stress cardiac magnetic resonance imaging (CMR), scinthigraphy or exercise ECG)
Atrial fibrillation, pacemaker, defibrillator, atrial ventricular (AV)-block II and III
Systolic blood pressure below 110 or above 160 mmHg at first screening visit
Diastolic blood pressure above 100 mmHg at first screening visit
Heart rate below 50 or above 100 beats / min (taken from ECG measurement) at first screening visit
Estimated glomerular filtration rate (eGFR) \< 30 mL/min/1.73m\*2 at first screening visit
