1. Chalazion that has atypical features (a recurring chalazion at the same spot, abnormal surrounding lid tissue, associated loss of tissues).

2. History of chalazion incision and curettage in study eyelid.

3. Multiple chalazia in any one eyelid.

4. Active ocular or eyelid infection Presence of hordeolum in any one eyelid.

5. An abnormal skin condition on the study eyelid region (e.g., eczema, psoriasis, atopic dermatitis, etc.) where the study drug will be applied.

6. Diagnosed with glaucoma in either eye.

7. History of steroid-induced elevation of IOP.

8. Female subjects who are pregnant or lactating.

Safety and Efficacy Study of SUN-131 Transdermal System (TDS) as Compared to Placebo TDS in Patients With a Chalazion