Effect of VPro5 Therapy on Clear Aligner Therapy

Exclusion Criteria

• •1. Subjects who have received periodontal treatment in the previous 6 months
• •2. Subjects who are taking medication that could affect the level of inflammation, such as chronic antibiotics, phenytoin, cyclosporin, ant-inflammatory drugs, systemic corticosteroids, or calcium channel blockers.
• •3. Subjects missing adult teeth (except the 3rd molars) or with severe class II or class III malocclusion.
• •4. Subjects with skeletal class I but extreme dental malocclusion
• •5. Severe crowding that require extraction
• •6. More than 4 mm positive overjet and more than 2 mm negative overjet
• •7. Extreme deep bite (more than 90%);
• •8. Severe openbite (more than 2 mm)
• •9. Pregnant women
• •10. Subjects do not have any systemic diseases effecting bone metabolism
• •11. Smoking
• •12. Vulnerable subjects per IRB definitions
• •13. Subjects with current caries
• •14. Subjects that require interproximal reduction or attachments during the study period
• •15. Subjects who are non-compliant regarding aligner wear or VPro5 recommended daily usage