Ixazomib In Combination With Cyclophosphamide And Dexamethasone for Newly Diagnosed AL Amyloidosis

Exclusion Criteria

• •Female patients who are lactating or have a positive serum pregnancy test during the screening period.
• •Major surgery within 14 days before enrollment.
• •Infection requiring systemic antibiotic therapy or other serious infection within 14 days before study enrollment.
• •Evidence of current uncontrolled cardiovascular conditions:
• •* uncontrolled hypertension, uncontrolled cardiac arrhythmias, symptomatic congestive heart failure, \*unstable angina, or myocardial infarction within the past 6 months.
• •Recent history of myocardial infarction in the six months prior to registration
• •Systemic treatment, within 14 days before the first dose of ixazomib, with strong inhibitors of CYP1A2 (fluvoxamine, enoxacin, ciprofloxacin), strong inhibitors of CYP3A (clarithromycin, telithromycin, itraconazole, voriconazole, ketoconazole, nefazodone, posaconazole) or strong CYP3A inducers (rifampin, rifapentine, rifabutin, carbamazepine, phenytoin, phenobarbital), or use of Ginkgo biloba or St. John's wort.
• •Ongoing or active systemic infection, active hepatitis B or C virus infection, or known human immunodeficiency virus (HIV) positive.
• •Any serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of treatment according to this protocol.
• •Known allergy to any of the study medications, their analogues, or excipients in the various formulations of any agent.
• •Known GI disease or GI procedure that could interfere with the oral absorption or tolerance of ixazomib including difficulty swallowing.
• •Diagnosed or treated for another malignancy within 2 years before study enrollment or previously diagnosed with another malignancy and have any evidence of residual disease. Patients with early stage prostate cancer, non melanoma skin cancer or carcinoma in situ of any type are not excluded; patients with malignancies that have undergone complete resection are not excluded.
• •Patient has ≥ Grade 3 peripheral neuropathy, or Grade 2 with pain on clinical examination during the screening period.
• •Participation in other clinical trials, including those with other investigational agents not included in this trial, within 21days of the start of this trial and throughout the duration of this trial.
• •New York Heart Association Class III or IV Heart Failure
• •NT Pro-BNP \> 8500pcg/mL.
• •Dialysis dependent renal failure