Cladribine Dose Escalation in Conditioning Regimen Prior to Allo-HSCT for Refractory Acute Leukemia and Myelodysplastic Syndromes

Exclusion Criteria

• •Contraindication for Allo-HSCT
• •Cord blood Allo-HSCT
• •Current active disease or positive serology for HIV, and/or HCV with detectable viremia and/ or HBV with positive Hbs Antigen.
• •Renal failure with creatinine clearance \< 30 ml/ min
• •Decompensated haemolytic anaemia
• •Hypersensitivity to an active substance or to any of the excipients
• •Acute urinary infection
• •Pre-existing haemorrhagic cystitis
• •Woman of childbearing potential not using an effective contraception .
• •Pregnant or lactating women
• •Any serious concurrent uncontrolled medical disorder
• •Any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule.