HMPL-813 in Treating Patients With Glioblastoma

Exclusion Criteria

• •1. Use of Antiepileptic drugs were used\] within 2 weeks before enrollment
• •2. Immunotherapy, anti-angiogenesis or EGFR TKI and its downstream pathway signaling molecules and other targeted drugs within 4 weeks before enrollment; temozolomide chemotherapy, cranial radiotherapy or other systemic anti-tumor therapy within 3 weeks before enrollment
• •3. Previous toxic effects of anticancer therapy have not yet been recovered (defined as not restored to 0 or 1 level, except alopecia) or have not been fully recovered from previous surgery
• •4. Uncontrolled active infections such as acute pneumonia, Hepatitis B Virus (HBV) and so on
• •5. Eye disease or dry eye syndrome history
• •6. Positive pregnancy tested result