Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Pennsylvania
With
National Heart, Lung, and Blood Institute (NHLBI)
Johns Hopkins University
University of Colorado, Denver
Rhode Island Hospital
Stanford University
Vanderbilt University
Washington University School of Medicine
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Previous documentation of mean pulmonary artery pressure \> 25 mm Hg with a pulmonary capillary wedge pressure (or left ventricular end-diastolic pressure) \< 16 mm Hg and PVR \> 3 WU at any time before study entry.
Diagnosis of PAH which is idiopathic, heritable, drug- or toxin-induced, or associated with connective tissue disease, congenital heart disease, portal hypertension, or HIV infection and receiving treatment for PAH.
Most recent pulmonary function tests with FEV1/FVC \>50% AND either a) total lung capacity \> 70% predicted or b) total lung capacity between 60% and 70% predicted with no more than mild interstitial lung disease on computerized tomography scan of the chest.
Ability to perform six minute walk testing without significant limitations in musculoskeletal function or coordination.
If female, post-menopausal state, defined as:
* \> 50 years old and a) have not menstruated during the preceding 12 months or b) have follicle-stimulating hormone (FSH) levels (\> 40 IU/L) or
* \< 50 years and FSH (\> 40 IU/L) or
* having had a bilateral oophorectomy.
Informed consent.
You may not be if
Age \< 18.
Current treatment with estrogen, hormone therapy, or anti-hormone therapy (tamoxifen, fulvestrant, etc.)
WHO Class IV functional status.
History of invasive breast cancer.
Clinically significant untreated sleep apnea.
Left-sided valvular disease (more than moderate mitral valve stenosis or insufficiency or aortic stenosis or insufficiency), pulmonary artery or valve stenosis, or ejection fraction \< 45% on most recent echocardiography (within 1 year).
Initiation of PAH therapy (prostacyclin analogues, endothelin-1 receptor antagonists, phosphodiesterase-5 inhibitors, riociguat, selexipag) within three months of enrollment; the dose must be stable for at least three months prior to Baseline Visit. PAH therapy which is stopped and then restarted or has dose changes which are not related to initiation and uptitration will be allowed within 3 months prior to the Baseline Visit.
Hospitalized or acutely ill.
Renal failure (creatinine ≥ 2.0).
Hypercalcemia.
Severe osteoporosis: T score -2.5 to -3.4 without bone modifying treatment OR T score = - 3.5 or lower
Child-Pugh Class C cirrhosis.
Current or recent (\< 3 months) chronic heavy alcohol consumption.
Enrollment in a clinical trial or concurrent use of another investigational drug or device within 30 days of screening visit.
Clareo Health | Pulmonary Hypertension and Anastrozole Trial
