Contraindication for FFR examination or administration of vasodilators.

Subject is presenting with acute infarct (STEMI) OR has documented prior STEMI on same side (right/left).

CTO in target vessel.

Prior CABG, heart transplant or valve surgery, or prior TAVI/TAVR.

Known LVEF ≤45%.

Arteries supplying akinetic or severe hypokinetic territories if already known based on prior imaging.

TIMI Grade 2 or lower at baseline.

Target lesion involves Left Main (stenosis \>50%).

PCI with stent in target vessel in past 12 months, or target vessel involves in-stent restenosis.

Severe, diffuse disease defined as the presence of diffuse, serial gross luminal irregularities present in the majority of the coronary tree.

Target coronary vessel is supplied by major collaterals.

FFRangio Accuracy vs. Standard FFR