Lead Sponsor

Mount Carmel Health System

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Yes

•\> 18 years old
•Male or female
•PPI on home medication reconciliation
•GERD that is symptom controlled (per questionnaire), OR
•Gastritis that is symptom controlled (per questionnaire), OR
•An unclear indication for PPI use but free of GERD/gastritis/ulcer symptoms (includes patients on GI prophylaxis from the hospital and continued medication)
•Desire or willingness to be off of PPI chronically
•On PPI chronically (\> 2 months or 8 weeks, can be intermittent use)
•Initial PPI dose cannot exceed more than the equivalent of Omeprazole 40mg PO BID
•Comprehend English well (per provider's discretion; to understand questionnaires, instructions, etc.)

•On PPI for fewer than 2 months
•Co-morbid diagnosis of Peptic Ulcer Disease, H.pylori infection, Barrett's esophagus, malignancy, Inflammatory Bowel Disease
•Diagnosis of moderate to severe renal impairment (defined as CrCl \<50 mL/min; reasoning due to caution of H2RB on renal failure)
•Diagnosis of prolonged QT interval with renal impairment (reasoning due to H2RB with concomitant renal failure may increase QT interval if not renally dosed)
•True allergy to Proton Pump Inhibitor and / or H2 Receptor Blocker
•Patients with frequent cardiac angina symptoms (decreasing the dose of PPI may cause rebound GERD and the patient may think they are having a heart attack)
•Pregnant women, fetuses, neonates or fetal material
•Females of reproductive potential at time of research that are not on a form on birth control (OCPs, tubal ligation, etc) or lactating
•Adults with decisional impairment
•Prisoners
•Patients with uncontrolled Psychological illness

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