Daprodustat Hepatic Impairment Study

Exclusion Criteria

• •Healthy control subjects will be matched for BMI +/-15% to subjects in the respective hepatic impairment cohort but must also remain in the range of body weight \>=45 kg and BMI within the range 18-38 kg/m\^2 (inclusive).
• •For all subjects:
• •QT interval corrected for heart rate according to Fridericia's formula (QTcF) \>500 milliseconds (msec).
• •Recent history of deep vein thrombosis, pulmonary embolism or other thrombosis related condition. Any prior medical history in these areas will be reviewed and approved by the PI and the sponsor's Medical Monitor on a case by case basis as needed.
• •Myocardial infarction or acute coronary syndrome, stroke or transient ischemic attack within the 12 weeks prior to enrollment.
• •Subjects with a pre-existing condition (other than liver disease) interfering with normal gastrointestinal anatomy or motility that could interfere with the absorption, metabolism, and/or excretion of daprodustat.
• •Subjects that have undergone cholecystectomy within the past 3 months.
• •Subjects with chronic inflammatory joint disease (example, scleroderma, systemic lupus erythematosis, rheumatoid arthritis).
• •History of malignancy within the prior 2 years or known kidney mass \>3 centimeter (cm) (end stage renal disease subjects with impairment only) OR currently receiving treatment for cancer. ONLY exception is localized squamous cell or basal cell carcinoma of the skin definitively treated 12 weeks prior to enrollment.
• •Class IV heart failure, as defined by the New York Heart Association (NYHA) functional classification system.
• •Current enrolment or past participation (i.e., administration of last dose of investigational study treatment) within the last 30 days (or 5 half-lives, whichever is longer) before Day 1 in this or any other clinical study involving an investigational study treatment or any other type of medical research.
• •Present of 8 times Upper limit of normal (ULN) elevations in Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), or bilirubin.
• •Subjects with any other medical condition which, in the judgment of the investigator and Medical Monitor, could jeopardize the integrity of the data derived from that subject or the safety of the subject.
• •Subjects with advanced ascites (Grade 3).
• •Subjects with refractory encephalopathy as judged by the investigator or significant Central Nervous System (CNS) disease (example dementia, or seizures) which the investigator considers will interfere with the informed consent, conduct, completion, or results of this trial or constitutes an unacceptable risk to the subject.
• •Subjects with functional Transjugular Intrahepatic Portosystemic Shunt (TIPS) placement.
• •Presence of hepatopulmonary or hepatorenal syndrome.
• •Presence of primarily cholestatic liver diseases.
• •History of liver transplantation.
• •Subjects with signs of active infection, including active spontaneous bacterial peritonitis.
• •Subjects with unstable cardiac function or subjects with hypertension whose blood pressure is not controlled (based on the investigator's discretion).
• •Diabetic subjects whose diabetes is not controlled (based on the investigator's discretion).
• •Exposure to more than 4 new chemical entities within 12 months prior to the first dosing day.
• •Presence of Hepatitis B surface antigen (HBsAg) at screening or Positive Hepatitis C antibody test result at screening or within 3 months before the first dose of study treatment.
• •Positive pre-study drug/alcohol screen.
• •Positive human immunodeficiency virus (HIV) antibody test.
• •Regular use of known drugs of abuse.
• •Regular alcohol consumption within 6 months prior to the study defined as an average weekly intake of \>14 drinks. One drink is equivalent to 12 g of alcohol: 12 ounces (360 mL) of beer, 5 ounces (150 mL) of wine or 1.5 ounces (45 mL) of 80 proof distilled spirits. One unit is equivalent to 8 g of alcohol: a half-pint (approximately 240 mL) of beer, 1 glass (125 mL) of wine or 1 (25 mL) measure of spirits.