N-acetylcysteine for the Treatment of Cannabis Dependence: Working Mechanisms

Exclusion Criteria

• •Currently dependent on any substance other than cannabis, alcohol or nicotine;
• •History of any major internal disease (including diabetes, cardiovascular disease, lung disease, liver or kidney disease);
• •An active or any history of neurological disorder, including but not limited to seizure disorder, epilepsy, stroke, neurological disease, cognitive impairment, head trauma with prolonged loss of consciousness (\>10 minutes), or migraine headaches;
• •An active or a history of a psychiatric disorder including, but not limited to, depression, schizophrenia, bipolar disorder, anxiety, or other psychiatric disorders;
• •Asthma;
• •Known hypersensitivity or allergy to n-acetylcysteine, or receiving chronic therapy with medication that could interact adversely with n-acetylcysteine within 30 days prior to randomization (i.e., nitroglycerin, ACE inhibitors or antihypertensive drugs, anti-coagulants);