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Metoclopramide for Post Traumatic Headache | Clinical Trials | Clareo Health

COMPLETEDPHASE3

Metoclopramide for Post Traumatic Headache

A Randomized Placebo Controlled Trial of IV Metoclopramide for Acute Post-traumatic Headache

NCT03220958•Montefiore Medical Center

Summary

Nearly 1.5 million patients present to US emergency departments annually following head trauma. Headache is a frequent symptom of victims of head trauma. The purpose of this study is to see if an intravenous medication called metoclopramide can improve the symptoms of patients with acute post-traumatic headache.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Included patients will be adults who meet International Classification of Headache Disorders criteria for acute post-traumatic headache. These are as follows:
•Traumatic injury to the head has occurred
•Headache has developed within 7 days of injury to the head
•Headache is not better accounted for by another diagnosis (eg, previous history of migraine or tension-type headache)
•The headache must be rated as moderate or severe in intensity at the time of initial evaluation.

Exclusion Criteria

•Patients will be excluded if more than ten days have elapsed since the head trauma, if the headache has already been treated with an anti-dopaminergic medication, or for medication contra-indications including pheochromocytoma, seizure disorder, Parkinson's disease, use of MAO inhibitors, and use of anti-rejection transplant medications.

Locations (1)

Montefiore Medical Center

The Bronx, New York, United States

Key Dates

Start Date

August 1, 2017

Primary Completion Date

April 1, 2020

Completion Date

April 1, 2020

Last Updated

November 9, 2021

Enrollment

160

ACTUAL participants

Conditions

Post-Traumatic Headache

Interventions

Metoclopramide

DRUG

Diphenhydramine

DRUG

Normal saline

DRUG

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 9, 2021Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Metoclopramide for Post Traumatic Headache

Inclusion Criteria

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