History of ocular surgery specifically intended to lower IOP

Subjects who cannot safely discontinue use of ocular hypotensive medications during the wait/washout period

Advanced glaucoma in either eye

Any corneal abnormality or other condition interfering with or preventing reliable Goldmann applanation tonometry

Any ocular surgery or ocular laser treatment within 90 days prior to Visit 1 (Screening) and throughout the study in either eye

Females who are pregnant, nursing, or planning a pregnancy

A Phase IIb Safety and Efficacy Study of DE-126 Ophthalmic Solution in Primary Open-Angle Glaucoma or Ocular Hypertension- Angel Study