Study to Investigate the Influence of Hepatic Insufficiency on the Pharmacokinetics of Tozadenant

Exclusion Criteria

• •Subjects must not be enrolled in the study if they:
• •Previously participated in any study with tozadenant
• •Has orthostatic hypotension, history or symptoms of cardiovascular disease, or hypertensive crisis.
• •Currently participating in or has participated in another study and received drug (active or placebo)
• •Have a known diagnosis of malignant melanoma
• •Have a current episode of major depression
• •Has a recent history of suicide attempt
• •Has any other condition or clinically significant abnormal findings on the physical or neurological examination, psychiatric and medical history
• •Had surgery or any medical condition within 6 months
• •Unable to refrain from or anticipates the use of any drugs, vitamins, natural or herbal supplements
• •Subject is currently lactating or pregnant or planning to become pregnant.
• •Recent donation of blood, plasma or significant blood loss
• •Has positive test for ethanol or drugs of abuse or a history of chronic alcohol or drug abuse
• •Clinically significant medical history
• •Positive results hepatitis B surface antigen (HBsAg) or hepatitis C virus (HCV) for Healthy Volunteers only.