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Lead
University of Utah
Depression is a debilitating illness associated with diminished quality of life and significant personal and societal costs. Depression is twice as common in those with type 2 diabetes compared to the general population. Antidepressants are commonly prescribed as treatment for depression; however, they may not be the optimal treatment for people with type 2 diabetes. Creatine has been shown to decrease symptoms of depression in many types of individuals when used over the course of 8 weeks or more. The purpose of this study is to investigate whether creatine can decrease symptoms of depression in individuals with type 2 diabetes when taken daily for 12 weeks. This study also investigates how creatine impacts brain chemistry as creatine decreases depressive symptoms.
Age
20–64
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
Current diagnosis of Major Depressive Disorder identified by the SCID-5-RV
Current HAM-D score of \> 16
Current type 2 diabetes (as confirmed by clinical history and baseline glycosylated hemoglobin percentage (HgA1c) \> 6.5.
Diabetes type II present for at least one year
You may not be if
Diagnosis of bipolar disorder, schizophrenia, or schizoaffective disorder, identified by the SCID-5-RV
History of or current diagnosis of acute kidney injury (AKI), chronic kidney disease (CKD) or end-stage renal disease (ESRD)
Electrolyte disturbance (hypokalemia, hyperkalemia, hyponatremia, or hypernatremia) on screening basic metabolic panel
History of cardiac disease or QTc \>500ms on screening EKG
History of diabetic ketoacidosis or hyperosmolar hyperglycemic state
History of seizure disorder
Current serious suicide risk identified by the Columbia Severity Suicide Rating Scale
Positive pregnancy test
Breastfeeding
Contraindication to an MRI scan
Current incarceration
Clareo Health | Creatine for Treatment of Depression Associated With Type 2 Diabetes
