Augmentation of Limb Perfusion With Contrast Ultrasound

Exclusion Criteria

• •1. Major medical illness other than PAD affecting the limb (muscle disease, blood diseases that influence flow or rheology, severe heart failure \[NYHA class IV or LVEF \<30%\]).
• •2. Pregnant or lactating females
• •3. Hypersensitivity to any ultrasound contrast agent
• •4. Known atrial septal defect or large right to left shunt.
• •5. Hemodynamic instability (hypotension with systolic BP \<90 mm Hg, need for vasopressors)
• •6. Evidence for ongoing myocardial ischemia
• •7. For normal controls, any known structural non-arrhythmic cardiovascular disease (coronary artery disease, heart failure, moderate or greater valve disease).