5. Photodistributed violaceous erythema, (skin that is exposed to sunlight and appears purplish/reddish, and patchy in appearance;
6. Positive DM serology -
Post DM diagnosis; standard of care workup for DM must have been completed prior to entry into this research study.
Willing to provide 8 biopsies during the course of the research study
MMT-8 ≤136/150 and PhGA, VAS ≥3 cm (0-10 cm) by visual analog scale (VAS)
Sum of PhGA, VAS, PtGA, and extramuscular global assessment VAS scores is ≥10 cm (0-10 cm) VAS for each.
* Participant has failed at least two or more adequate courses of an immunosuppressive agent or immunomodulatory agent, including IVIG, at a dose known to be effective for rheumatologic diseases.
You may not be if
Investigator site staff or members of their family.
Acute and Chronic present medical conditions
Intake of greater than 15 mg of prednisone or equivalent per day
Pregnant or breastfeeding females. Fertile men and women who will not comply with the use of 2 effective birth control methods as per the research protocol
Have required management of acute or chronic infections
Have pre existing demyelinating disorder such as multiple sclerosis, or other severe neurological deficits.
Clinically significant lab abnormalities
Any health condition that may be worsened by immunosuppression
Similar to patients with skin predominant activity; Intake of \>20 mg oral prednisone/day, or equivalent
