OTL38 for Intra-operative Imaging of Folate Receptor Positive Ovarian Cancer

Exclusion Criteria

• •Previous exposure to OTL38
• •Known FR-negative ovarian cancer
• •Planned surgical debulking via laparoscopy or robotic surgery, with no intent of laparotomy.
• •Patients with known ovarian cancer miliary disease determined preoperatively to be inoperable.
• •Any medical condition that, in the opinion of the investigators, could potentially jeopardize the safety of the patient
• •History of anaphylactic reactions
• •History of allergy to any of the components of OTL38, including folic acid
• •Pregnancy or positive pregnancy test
• •Clinically significant abnormalities on electrocardiogram (ECG)
• •Presence of any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule
• •Impaired renal function defined as eGFR\< 50 mL/min/1.73m2
• •Impaired liver function defined as values \> 3x the upper limit of normal (ULN) for alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), or total bilirubin.
• •Known Stage IV ovarian cancer with brain metastases
• •Received an investigational agent in another clinical trial within 30 days prior to surgery
• •Known sensitivity to fluorescent light