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RECRUITINGNCT03178630

MRI Biomarkers in as Predictor of Clinical Endpoints in Pediatric Autoimmune Liver Disease

Autoimmune liver diseases (AILD), which include Primary Sclerosing Cholangitis (PSC) and Autoimmune Hepatitis (AIH) are a common etiological factor for chronic liver disease among adolescents. This is...

Lead sponsor: Children's Hospital Medical Center, Cincinnati•1 U.S. locations•View source on ClinicalTrials.gov

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Contacts

Alexander Miethke, MD

CONTACT

513-636-8948 alexander.miethke@cchmc.org

Cyd Castro Rojas, PhD

CONTACT

513-517-0580 cyd.castrorojas@cchmc.org

Sponsors

Lead Sponsor

Children's Hospital Medical Center, Cincinnati

Age

6 - 23 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•1. Age 6-23 years old.
•2. Established clinical diagnosis of AIH or PSC.

Exclusion Criteria

•1. History of liver transplantation.
•2. Chronic Hepatitis B or untreated hepatitis C virus infection.
•3. Pregnancy.
•4. Absolute contraindication for MRI (e.g. pacemaker, metallic implants, claustrophobia).
•5. Diagnosis of cystic fibrosis or biliary atresia
•6. Diagnosis of cardiac hepatopathy.
•7. Diagnosis of Wilson's disease, Alpha-1 Antitrypsin deficiency, or Glycogen storage disease.
•8. Skin conditions which could be aggravated by MREL (i.e. Epidermolysis bullosa).

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: December 12, 2024Terms

Trial snapshot

StatusRECRUITING

Phase—

Enrollment150

Start dateFeb 2017

Last updatedDec 12, 2024

Condition

Autoimmune Liver Disease Autoimmune Hepatitis Primary Sclerosing Cholangitis

Locations shown

Cincinnati Children's Hospital and Medical Center

Cincinnati, Ohio

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 12, 2024Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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