Effect of Tibet Rhodiola Capsule on Hypoxia and Cardiovascular Risk Factors in Patients With Obstructive Sleep Apnea

Exclusion Criteria

• •1. History of CPAP, Mandibular orthosis device, surgery, or other medications to improve OSA;
• •2. Significant central sleep apnea;
• •3. Histories of other sleep disorders: insomnia, chronic sleep deprivation, long-term use of sleeping pills or sedatives, restless legs syndrome;
• •4. Histories of underlying heart disease (cardiomyopathy, myocarditis, pericarditis or severe valvular disease), cardiogenic shock and heart failure (NYHA or Killip class 3-4), persistent atrial or ventricular arrhythmias;
• •5. History of myocardial infarction, coronary revascularization, and a known degree of stenosis \> 75% of the coronary lesions;
• •6. Histories of known serious liver dysfunction (ALT or AST levels above 3 times the normal limit), renal insufficiency (GFR\<30ml/min), moderate and severe chronic obstructive pulmonary disease, and pulmonary arterial hypertension;
• •7. Patients with malignant tumors, lymphoma and neuropsychiatric disorders;
• •8. Patients with major surgery or trauma within 3 months, and active bleeding or cerebrovascular accident within 6 months;
• •9. History of anemia (hemoglobin\<90g/L) or thrombocytopenia (thrombocyte \<90×10\^9/L);
• •10. Breastfeeding, pregnant, or potentially fertile women;
• •11. Patients who have known to be allergic to Tibet Rhodiola Capsule or its components or patients with serious adverse effect;
• •12. Participation in other clinical trials in recent 3 months;
• •13. Patients who cannot complete this trial or comply with the protocol.