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Differential Diagnostics of Etiology of Acute Infections | Clinical Trials | Clareo Health

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Differential Diagnostics of Etiology of Acute Infections

Differential Diagnostics of Etiology of Acute Infections Based on the Analysis of Expression of Activation Markers on the Surface of Peripheral Blood Monocytes and Neutrophils.

NCT03161951•The Republican Research and Practical Center for Epidemiology and Microbiology

View on ClinicalTrials.gov

Summary

Method for diagnostics of the origin of infections (bacterial vs viral) based on the identification of activation markers of blood neutrophils and monocytes will be developed.

Detailed Description

During the study, method for diagnostics of the origin of infections (bacterial vs viral) based on the identification of activation markers of blood neutrophils and monocytes will be developed.This method will allow to make a diagnosis within an hour after blood sampling. The expression of the following markers of activation will be studied using flow cytometry: CD11b, CD11c, CD13, CD16, CD32, CD35, CD38, CD62L, CD64, CD66b, CD88, CD284, HLA-ABC and HLA-DR.

Eligibility

Age

18 - 80 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•neuroinfections or acute intestinal infections;
•the possibility of blood sampling within a period of up to 24 hours from the moment of admission to hospital;
•less than 72 hours passed after the onset of the disease and until blood was collected;

Exclusion Criteria

•refuse of patient to participate in the trial;
•more than 24 hours passed after the patient entered the hospital;
•the disease began more than 72 hours ago;
•concomitant severe acute and chronic diseases;
•malignant neoplasms, treatment at a time of less than 1 year, autoimmune diseases in the phase of exacerbation;
•pregnancy/lactation;
•HIV, Hepatites B/C;
•active tuberculosis;
•alcohol use disorder/drug addiction.

Key Dates

Start Date

January 3, 2017

Primary Completion Date

December 10, 2018

Completion Date

December 29, 2018

Last Updated

January 9, 2019

Enrollment

169

ACTUAL participants

Conditions

Intestinal Infectious DiseasesNeuroinfections