Tumor Response Prediction in Neoadjuvant Chemoradiation of Locally Advanced Rectal Cancer Using Metabonomics Analysis

Inclusion Criteria

• •1. history of primary rectal cancer with distance from anal verge being less than 12 cm;
• •2. histologically confirmed adenocarcinoma;
• •3. initial pathological stage of T3 or T4 and/or N+;
• •4. no history of initial distant metastases;
• •5. Karnofsky Performance Status score of ≥75
• •6. ≥18 years;≤75 years
• •7. sign the inform consent