Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Minnesota
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Type 1 diabetes diagnosed on clinical grounds (history of DKA, use of insulin within 6 months of diagnosis)
Diabetes duration \< 30 years (impaired awareness of hypoglycemia increases with duration so it will be more likely that shorter duration participants will have hypoglycemia awareness) but \> 2 years (to ensure that they have lost hypoglycemia induced glucagon secretion as is typical in patients who develop impaired awareness of hypoglycemia)
Age 18 - 65 years
Baseline hemoglobin A1C 6.8 - 9.0% (range selected to reduce the risk of hypoglycemia and uncontrolled diabetes in the weeks before the study, both of which may affect the responses to hypoglycemia)
Awareness of hypoglycemia as verified by Cox questionnaire
You may not be if
History of stroke, seizures (other than those related to hypoglycemia), arrhythmias, active cardiac disease
History of hypertension or blood pressure \> 140/95 mm Hg at screening visit
Pregnancy or plan to become pregnant during the study period
Health related limitations in exercise (including but not limited to: angina, uncontrolled asthma, peripheral arterial disease)
Unwillingness to avoid exercise during the 7 days before each part of the study
Concomitant medical problems that may prevent the participant from successfully completing the protocol
Smoking as defined by 2 or more tobacco cigarettes a week
Daily use of opioids or an opioid antagonist or use in the past two weeks
Unwillingness to wear a continuous glucose monitor for one week before and one week after each part of the study
Clareo Health | Naloxone, Hypoglycemia and Exercise
