Phase II Proof of Concept Study in Uncomplicated UTI

Exclusion Criteria

• •Participated in any other trial within 30 days of visit 1
• •Known or suspected allergy to investigational drug
• •Narrow angle glaucoma
• •Recovering from chicken pox or flu-like symptoms
• •History of peptic ulcer, gastrointestinal bleeding, gastrointestinal surgery, or gastrointestinal dysfunction which could interfere with drug absorption
• •Taken any drugs for within past 24 hours for symptoms associated with uncomplicated urinary tract infections
• •Currently taking prohibited drugs
• •Taken an antibiotic within 7 days of Visit 1
• •Are ineligible to receive an antibiotic
• •History of urinary retention
• •History of interstitial cystitis
• •History of impaired renal function
• •History of impaired hepatic function
• •Diagnosis or suspicion of complicated urinary tract infection or systemic infection
• •History of substance abuse