Locally Advanced NSCLC Hyperfractionated RT

Inclusion Criteria

• •1. Histologic/cytologic documentation of non-small cell lung cancer (NSCLC)
• •2. Unresectable stage II, IIIA, or IIIB disease
• •3. Zubrod/ECOG performance status 0-1
• •4. Weight loss \< 10% in preceding 3 months prior to diagnosis
• •5. Adequate organ function defined as the following
• •6. Absolute neutrophil count of ≥ 1,500 and platelet count ≥ 100,000
• •7. Cockcroft calculated creatinine clearance of ≥ 45 ml/min or 1.5 x the upper limit of normal (ULN)
• •8. A total bilirubin ≤ 1.5 ULN, aspartate aminotransferase (AST) ≤ 2.0 x ULN
• •9. ≥ 18 years of age.
• •10. Negative pregnancy test in women of child-bearing potential
• •11. Signed study-specific informed consent.
• •12. No prior chemotherapy or radiotherapy for NSCLC
• •13. No prior mediastinal or thoracic radiation