Laser-Assisted Regenerative Surgical Therapy for Peri-implantitis

Exclusion Criteria

• •Long-term use of antibiotics \> 2 weeks in the past two months
• •Obvious malpositioning of the dental implants
• •Subjects taking medications known to modify bone metabolism (such as bisphosphonates, corticosteroids, Hormone replacement therapy for menopausal women, parathyroid hormone, Denosumab, strontium ranelate)
• •Pregnant females or those planning to become pregnant
• •Subjects with a history of major diseases, oral cancer, sepsis or those having adverse outcomes to oral procedures in the past, will be excluded
• •Mobility of dental implants
• •History of alcoholism or drug abuse
• •Current smokers
• •Diseases of the immune system or any medical condition that may influence the outcome (uncontrolled diabetes (HbA1c \>8)
• •Uncontrolled systemic disease or condition known to alter bone metabolism, like Osteoporosis, Osteopenia, Hyperparathyroidism, Paget's disease
• •The researcher believes that it is not the best interest of the subject to stay in the study
• •If the subject's medical condition requires interventions which preclude involvement in the study (radiation therapy, chemotherapy, etc)
• •If the subject does not follow study related instructions
• •The study is suspended or canceled.