Diagnosed with progressive multiple sclerosis with or without relapses
EDSS score between 1.5 and 7.0, including documented rapid progression over the previous year unresponsive to conventional therapies or no available treatment options
Aged between 18 and 60 with a history of at least one enhancing lesion on brain MRI
With absolute neutrophil count ≥ 1,000/mm\^3, platelet count ≥ 100,000/mm\^3 and hemoglobin ≥ 9.0 g/dL
You may not be if
Patients with cardiac, renal, pulmonary, hepatic, or other organ impairment that would limit their ability to receive dose-intensive immunosuppressive therapy, high-dose chemotherapy, and/or Autologous HSCT
Patients with any active or chronic infection e.g. uncontrolled viral, fungal, or bacterial infection
Uncontrolled diabetes
Patients who are seropositive for HIV1, HIV2, Hepatitis B Surface Antigen, and Hepatitis C
Patients whose life expectancy is severely limited by another illness
Patients with evidence of myelodysplasia or other non-autoimmune cytopenia
Patients having received a cytotoxic agent within one month prior to this study
Patients who are pregnant or at risk of pregnancy, including those unwilling to practice
Patients with psychiatric illness, mental deficiency, or cognitive dysfunction
Patients unable to give written informed consent in accordance with research ethics board guidelines
