Study of Pomaglumetad and Methamphetamine

Exclusion Criteria

• •1. non-English speaking;
• •2. currently on probation or parole;
• •3. have current cocaine, opioid, marijuana, or alcohol use disorder, moderate-severe;
• •4. have liver function tests (total bilirubin, ALT, AST, or alkaline phosphatase) ≥ 2 x the upper limit of normal or kidney function tests (creatinine and BUN) ≥ 2 x the upper limit of normal;
• •5. current or past history of seizure disorder;
• •6. a history of head trauma that resulted in neurological sequelae;
• •7. major psychiatric disorder not due to substance abuse (e.g., schizophrenia, bipolar illness but excepting stable major depressive disorder, generalized anxiety disorder, etc.) as assessed by the MINI;
• •8. have a current neurological disorder (e.g., organic brain disease, dementia) or medical condition which would make study compliance difficult or compromise informed consent;
• •9. current ongoing treatment with psychotropic medications (e.g. antidepressants, antipsychotics, antiepileptics, sedative/hypnotics, narcotic analgesics);
• •10. history of suicide attempt(s) in the past 6 months or active suicidal intention or plan (score 4 or 5) in the past month as assessed by the C-SSRS;
• •11. evidence of clinically significant heart disease or hypertension;
• •12. evidence of untreated or unstable serious medical illness including: neuroendocrine, autoimmune, renal, hepatic, or active infectious disease including active tuberculosis infection;
• •13. have HIV infection and currently symptomatic, have a diagnosis of AIDS, or are receiving antiretroviral medication;
• •14. have a medical condition that makes maintaining reliable intravenous access impossible;
• •15. donated blood or plasma within 3 months of inpatient admission;
• •16. use of OAT1 inhibitor (e.g. probenecid, uricosurics, antivirals, nonsteroidal anti-inflammatories, loop diuretics, angiotensin II receptor antagonists, proton pump inhibitors, or statins) or CYP2D6 inducers or inhibitors within 14 days or five half-lives, whichever is longer, from admission;
• •17. currently employed by UCLA or Denovo or a first-degree relative of UCLA or Denovo employee or;
• •18. any other circumstances that, in the opinion of the investigators, would compromise participant safety and/or successful completion of the trial.