Cold Induced Activation of Brown Adipose Tissue in Humans

Exclusion Criteria

• •Chronic diseases: Hormonal: Metabolic Diseases mb. Graves, hypothyroidism, myxedema and goiter. Diabetes Melitus, Coronary heart disease (history of myocardial infarction, unstable angina pectoris, or congestive heart failure), cancer treated within last 3 years.
• •Tobacco, marijuana or intravenous drug use within 1 year of screening.
• •Dieting, recent weight loss (\>3 kg within 3 month) or a history of an eating disorder.
• •Dietary supplements.
• •History of depression, psychosis, or other psychiatric illness requiring hospitalization.
• •Alcohol consumption \>14 units/week.
• •History of alcohol abuse within the past 3 years.
• •Known liver disease or elevated liver biomarkers more than 2 times upper normal levels in the preliminary investigation.
• •Known kidney disease or elevated kidney biomarkers, eCRF \<60 ml/min, in the preliminary investigation.
• •Use of daily medications, except for seasonal use of antihistamines.
• •Diagnosed sleep disturbances.
• •Pacemaker or other electronics implanted in the body.
• •Magnetic impressionable metal implants or foreign objects in the body inconsistent with completion of MR.
• •Claustrophobia
• •Communication problems, including understanding the experimental protocol
• •History of contrast allergy.
• •Winter swimmers.