Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Colorado, Denver
With
American Academy of Clinical Toxicology
Age
10–17
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Age \>=10 and \< 18 years
Present to the Emergency Department or Intensive Care Unit for an antimuscarinic toxidrome from either a pharmaceutical agent such as antihistamine overdose, or natural toxins or products such as Datura stramonium
Antimuscarinic toxidrome will be defined with at least one central nervous system agitation effect (agitation, delirium, visual hallucinations, mumbling incomprehensible speech), and at least 2 peripheral nervous system adverse effect (mydriasis, dry mucus membranes, dry axillae, tachycardia, decreased bowel sounds).
Patients will also be required to have a RASS score of +2 to +4 on initial assessment.
You may not be if
History of seizures or seizure during acute clinical course
History of asthma or wheezing during clinical course Bradycardia (Heart Rate \<60)
Concomitant use of atropine or choline ester or depolarizing neuromuscular blocker during present illness and hospital course
Diabetes gangrene, known intestinal obstruction or urogenital tract, vagotonic state
QRS interval \> 120 ms on electrocardiogram
Known to be pregnant at the time of enrollment
Known ward of the state
Clareo Health | Treatment of Adolescent Antimuscarinic (Anticholinergic) Toxidrome
