Severe cardiac disease, including NYHA Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina
Severe pulmonary disease, pneumonitis or interstitial lung disease
Severe rheumatologic or orthopedic diseases (e.g., awaiting joint replacement, active inflammatory disease)
Neurological conditions that cause impaired muscle function or mobility (e.g., Parkinson's Disease, multiple sclerosis, ALS)
Other significant co-morbid medical disease (e.g. renal failure with eGFR \< 30 ml/minute or on hemodialysis) or severe psychiatric disorder (e.g. bipolar, schizophrenia)
Terminal illness with life expectancy less than 12 months, as determined by a physician
Excessive alcohol use, defined as more than 5 drinks/day for males or more than 4 drinks/day for females, or more than 14 drinks per week
Current smoker or less than 3 years smoking cessation
Participating in another clinical trial or receiving an investigational product within 3 months prior to screening/enrollment
Diabetes mellitus currently taking medications to lower blood glucose (oral or by injection)
Current use of anticoagulant or anti-platelet medications (aspirin 81 mg daily is allowed)
Congenital or acquired bleeding disorders
Cholelithiasis or other gall bladder or biliary tract disease
Chronic gastrointestinal blood loss or iron deficiency (serum ferritin \< 12 ng/mL, with or without anemia)
History of estrogen-sensitive conditions including breast, uterine, and ovarian cancers; endometriosis; and uterine fibroids
History of Tuberculosis (TB), HIV, Hepatitis B or C, or other disease potentially compromising immune function
Current use of medications targeting immune or inflammatory function (e.g., sulfasalazine)
Current use of anabolic medications (i.e., growth hormones or testosterone), antidepressant medications and antipsychotic agents (including monoamine oxidase inhibitors), or anticholinesterase inhibitors (i.e., Aricept)
Acute infection (urinary, respiratory, other) or hospitalization within 1 month
Myocardial infarction, CABG, or valve replacement within past 6 months
Pulmonary embolism or deep venous thrombosis within past 6 months
Stroke, hip fracture, hip or knee replacement, or spinal surgery within past 4 months
Receiving physical therapy for gait, balance, or other lower extremity training
