Lead Sponsor

Medical University of Vienna

Collaborators

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•for CKD patients with type 2 diabetes
•Estimated GFR (calculated with the MDRD-IDMS formula) between 15 and 59 ml/min (with CKD stage IIIa/b to IV)
•Albumin excretion rates of 30-300 mg/24 hours (UACR \<300 mg/g)
•Fasting plasma glucose levels \>126 mg/dl \[7mmol/L\] or HbA1c levels \>6.5% (Definition of type 2 diabetes according to the diagnostic criteria set forth by the American Diabetes Association in 2009)
•for CKD patients without Diabetes
•Estimated GFR (calculated with the MDRD-IDMS formula) between 15 and 59 ml/min (with CKD stage IIIa/b to IV)
•Albumin excretion rates of 30-300 mg/24 hours (UACR \<300 mg/g)

•CKD patients with type 2 diabetes
•Age \<18 years
•Severely impaired renal function (eGFR \<15ml/min)
•Hyperkalemia above 4.5mmol/L
•Hypotension (systolic blood pressure lower than 120 mmHg on ambulatory measurement)
•Pregnant patients
•Patients planning pregnancy
•Body mass index \< 18.5 kg/m2
•for CKD patients without diabetes
•Age \<18 years
•Diabetic kidney disease
•Severely impaired renal function (eGFR \<15ml/min)
•Hypotension (systolic blood pressure lower than 120 mmHg on ambulatory measurement)
•Pregnant patients
•Patients planning pregnancy
•Body mass index \< 18.5 kg/m2 -